Prenatal CGH Array

An array CGH is a technique that allows the detection of chromosomal abnormalities with a higher resolution than conventional techniques. 

Price

On request, depending on the test

Time to result

On request, depending on the test

What is a CGH array?

Array CGH, sometimes called molecular karyotyping, is a particularly differentiated and precise screening method in genetic diagnosis. Unlike conventional chromosome analysis, it can also detect very small changes in the genome, both microdeletions (absence of a very small piece of chromosome) and microduplications (addition of a piece of chromosome).

Prenatal array CGH can only be performed in combination with amniocentesis or chorionic villus sampling.

What prenatal CHG array do we offer at Genosalut?

For prenatal array CGH we have a 60k coverage platform that detects copy number variations, as well as small deletions and duplications associated with chromosomal abnormalities in the foetus. It is also applicable to the study of abortive remains in cases of repeated abortions. 

We have a CGH array platform (60k) for prenatal assessment of copy number changes in genome-wide chromosomal regions and high resolution in syndromic regions. This array allows us to analyse

  • Aneuploidies
  • Unbalanced translocations
  • Chromosomal mosaicism
  • Rearrangements of pericentromeric and subtelomeric regions
  • More than 290 microdeletion and duplication syndromes associated with mental retardation and autism.
Our value proposal

Experience

At Genosalut, we have more than 10 years of experience in counselling people with conditions where a genetic cause has been identified or is thought to be possible.

Proximity

We are a close laboratory, we respond personally and we take the time to explain the report in detail to doctors and patients.

Professional interpretation of results

Because of our knowledge and experience, we are able to accurately interpret genetic results and offer professional advice.

Reference in the field

We are the point of contact for patients, doctors and clinics in all areas of human genetic diagnostics and prevention.

Prevention and peace of mind with the genetic tests of Genosalut

You can know the risk of having affected offspring

The array CGH allows us to confirm or rule out with high reliability the presence of certain types of chromosomal abnormalities in the baby responsible for more than 290 genetic syndromes associated with intellectual disability and congenital alterations. On those occasions when the results are not entirely clear, it is sometimes possible to carry out complementary tests.

You can make decisions based on the results obtained

The results obtained will allow you, together with your family, your specialist and/or your genetic counsellor, to determine the possibilities and make a decision based on multiple factors.

How can I request a CGH array?
Request an appointment

Contact us through the form, by e-mail or by telephone to make an appointment with us.

Ask your physician

You can also consult your doctor for information on the possibilities of genetic testing.

We analyse the probe

In our genetic diagnostics laboratory we analyse the sample with the latest technology.

We write a report

We provide a detailed description of the results and, if necessary, genetic counselling.

FAQs

An array CGH is indicated by a gynaecologist in one of the following cases:

  • Abnormal ultrasound findings, e.g. organ malformation in combination with growth retardation or multiple malformations.
  • Abnormal chromosomal findings that need to be further clarified.
  • History of chromosomal abnormalities in the family.
  • Family history of increased risk of developing abnormalities.
  • Repeated miscarriages.

We also perform array CGH if the prospective parents have a great need for reassurance and want very detailed information about the chromosomal picture of the foetus.

The test can be done on DNA from cells obtained by:

  • Amniocentesis: from 15 weeks gestation onwards
  • Chorionic villus sampling: from 12 weeks gestation onwards

Cytogenetic analysis or conventional karyotyping is used to determine that the number, size and shape of an individual’s chromosomes are correct. This test is performed to rule out major alterations associated with problems such as miscarriages, malformations and/or mental retardation. 

The main difference between the two tests is their resolution.

  • The resolution of conventional karyotyping or cytogenetic analysis is limited and can only detect changes in the number and/or structure of chromosomes larger than 5-10 million base pairs (Mb).
  • The resolution of array CGH or molecular karyotyping is much higher, as it allows the simultaneous detection of very small alterations (gains or losses of DNA fragments) responsible for more than 300 genetic syndromes associated with mental retardation, autism, heart disease and other pathologies, most of which are not detectable by conventional karyotyping.
  • Positive or altered result: indicates the presence of a chromosomal abnormality. However, sometimes it may not be known whether the abnormality detected may be the cause of the abnormal ultrasound findings or what consequences it may have on the baby’s health. An additional blood test is then recommended for the parents. If a healthy parent carries the same change in the genetic material, it can usually be assumed that this variation is of no health significance.
  • Normal or negative result: indicates that no chromosomal abnormality has been detected by this technique. It should be noted that there are some genetic diseases that cannot be diagnosed by array CGH, such as those caused by differences in DNA that are too small to be detected even by array CGH. In such a case, other tests (exome or genome) can be performed to dispel the doubts.

The costs of an array CGH are covered by some private insurances and sometimes depend on certain criteria (patient’s medical history, family history, abnormal findings in ultrasound scans…). You can come to us with a certificate from your doctor or with your insurance card.

Request an appointment with us

Opening hours

Monday to Friday from 9.00 am to 1.00 pm

Phone number

+34 616 59 01 65

E-mail

info@genosalut.com

Address

Camí dels Reis, 308 (Clínica Palma Planas)

Contact form

Reasons for trusting Genosalut

First genetic diagnosis laboratory in the Balearic Islands

Professionals with experience in medical genetics

Detailed report of the results

Personalised attention for each patient

Wide range of genetic tests

Cutting-edge technology